Antifungal agents : Novel fused pyrimidone and triazinone derivatives - Techno Market

Offre n°2719
Antifungal agents : Novel fused pyrimidone and triazinone derivatives
Thématique :
Applications :

L'innovation

Due to their ease of use including administration route and relative inocuity, the azole derivatives (such fluconazole, itraconazole, voriconazole, posaconazole) are widespread antifungal agents. However, their use as first intention has lead to resistance.
Besides azole anti-fungal agents, alternative classes include polyenes such as amphotericine B (Fingizone) and its lipidic forms, as well as the echinocandines. Hoever, these alternative antifungal agents are fenerally costly and not suitable for oral administation for treating systemic disorders.
We have developed new azole antifungal derivatives in particular compounds able to circumvent resistance phenomenons, such as those originating from mutations of the gene coding for their target (14a-demethylase, CYP51) and/or their efflux 20 by pumps of the CDR or MDR pumps.

These compounds present high antifungal activity on numerous azole resistant strains without side effect.

Ses bénéfices

  • Active on azole-susceptible and resistant strains (Candida spp., Aspergillus fumigatus )
  • No cytotoxic effect
  • Chemical properties for oral, transdermal or intravenous administration

Ses applications

  • Treatment or prevention of fungal infections
  • Second application : treatment or prevention of parasitic infectious due to Trypanosomatidae.
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Stade de développement

  • IN VIVO - Preuve de concept

Laboratoire de recherche

EA 1155 - IICIMED

Équipe de recherche

DEPARTEMENT DE PARASITOLOGIE ET MYCOLOGIE MEDICALE

Propriété intellectuelle associée

WO : PCT/EP2015/067752 - filed on the 07-31-2015
WO - CA,EP,JP,US

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